Cốt Tý Hoàn Lương Y Hoàng Thông

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25/07/2022

🆘 AI ĐANG BỊ ĐAU 🦴 KHỚP🆘
👉 Chỉ cần để lại số điện thoại sẽ có chuyên gia gọi điện thăm khám, MIỄN PHÍ cho bạn.
📌 Hoặc liên hệ hotline của tôi (Hoàn toàn miễn phí)
☎️ - Mobifone: 0794255206
- Viettell: 0345146309
- Vinafone: 0828282589

Liệu Bạn có đang   đúng tư thế ?-Liệu bạn có duy trì tư thế ngồi đúng khi đọc bài viết này? Đời sống và tính chất công v...
18/07/2022

Liệu Bạn có đang đúng tư thế ?
-Liệu bạn có duy trì tư thế ngồi đúng khi đọc bài viết này? Đời sống và tính chất công việc vô tình đặt chúng ta vào tình trạng ngồi quá lâu trong thời gian dài và ngồi sai tư thế nhưng lại không nhận ra. Với một số người, điều này chỉ đơn giản là thói quen. Dù vậy, tác hại của ngồi sai tư thế đối với sức khỏe là vô cùng nghiêm trọng.
- Không chỉ ảnh hưởng đến dáng đi, ngồi sai tư thế lâu ngày có thể làm tăng nguy cơ thoái hóa cột sống, gù lưng, giãn tĩnh mạch hoặc thậm chí ung thư. Vì thế, cải thiện tư thế ngồi đúng và tầm soát xương khớp định kỳ là biện pháp cần thiết để bảo vệ cột sống, nâng tầm vóc dáng cũng như tăng tự tin khi giao tiếp.
-Duy trì tư thế ngồi đúng thường xuyên góp phần đem đến 9 lợi ích tốt cho sức khỏe như:

-Duy trì vóc dáng, giúp cột sống khỏe mạnh.
-Giảm hao mòn của bề mặt khớp (điển hình như đầu gối), từ đó ngăn ngừa bệnh viêm thấp khớp khởi phát.
-Giảm đau lưng, căng cơ và một số vấn đề nhức mỏi khác do ngồi lâu.
Giảm căng thẳng cho dây chằng ở cột sống.
Ngăn không cho cột sống cố định ở vị trí bất thường, dẫn đến dị dạng.
-Giữ cho xương và khớp ở đúng vị trí. Nhờ đó, các cơ được sử dụng đúng cách, hiệu quả hơn. Điều này cho phép cơ thể giảm tiêu hao năng lượng, hạn chế mệt mỏi và tăng khả năng tập trung.
-Giữ cân bằng cơ thể khi di chuyển và vận động thể thao.
Thúc đẩy lưu thông máu diễn ra tốt hơn.
Tư thế ngồi đúng giúp đường cong tự nhiên của cột sống được duy trì, đường thở cũng như hệ hô hấp giữ ở vị trí đúng. Qua đó, cung cấp oxy cần thiết cho não, hỗ trợ hít thở dễ dàng và nâng cao năng lượng tích cực suốt ngày dài.
-TÁC HẠI KHI NGỒI SAI TƯ THẾ :
Trước ảnh hưởng nặng nề của dịch COVID-19, một số học sinh, sinh viên và nhân viên văn phòng phải học tập, làm việc online tại nhà. Do đó, quá trình tiếp xúc với thiết bị điện tử trở nên thường xuyên. Song, không phải ai cũng tự giác điều chỉnh tư thế đúng khi ngồi.
-Hậu quả là ngồi quá lâu hoặc sai cách khiến khung xương bị biến dạng, đặc biệt ở cột sống có nguy cơ mắc phải thoát vị đĩa đệm, trượt cột sống, thoái hóa cột sống, viêm cột sống dính khớp, vẹo cột sống, gù lưng, co rút cơ lưng.

14/07/2022

B.À CON ĐANG GẶP VẤN ĐỀ VỀ 🦴 KHỚP 🤔
Chỉ cần để lại số điện thoại sẽ có chuyên gia của chúng tôi gọi điện thăm khám miễn phí cho bà con.
👉Hoặc liên hệ hotline của chúng tôi: 0337927948

  HÓA XƯƠNG KHỚP LÀ GÌ...? -Thoái hóa khớp là tình trạng tổn thương sụn khớp kèm theo phản ứng viêm và giảm thiểu lượng ...
05/07/2022

HÓA XƯƠNG KHỚP LÀ GÌ...?
-Thoái hóa khớp là tình trạng tổn thương sụn khớp kèm theo phản ứng viêm và giảm thiểu lượng dịch khớp do quá trình tái tạo sụn không đủ bù đắp cho lớp sụn ở khớp bị hao mòn. Theo thời gian, lớp sụn khớp phủ trên bề mặt xương sẽ dần bị mỏng và hư tổn, gây đau nhức và hạn chế vận động, thậm chí có thể bị tàn phế.
Sự mất cân bằng này có thể bắt nguồn từ nhiều yếu tố như di truyền, tổn thương tại vị trí khớp hoặc quá trình lão hóa theo thời gian.
-Khoa học hiện đại chỉ ra, nguyên nhân sâu xa và quan trọng hàng đầu của các bệnh xương khớp là do hệ miễn dịch của cơ thể bị rối loạn, làm sản sinh ra các chất gây viêm tấn công xương khớp của chính mình.

15/08/2019
Joints (Articulations)•      Weakest parts of the skeleton•      Articulation – site where two or more bones meet•      ...
10/08/2019

Joints (Articulations)
• Weakest parts of the skeleton
• Articulation – site where two or more bones meet
• Functions
• Give the skeleton mobility
• Hold the skeleton together
Classification of Joints: Structural
• Structural classification focuses on the material binding bones together and whether or not a joint cavity is present
• The three structural classifications are:
• Fibrous
• Cartilaginous
• Synovial
Classification of Joints: Functional
• Functional classification is based on the amount of movement allowed by the joint
• The three functional class of joints are:
• Synarthroses – immovable
• Amphiarthroses – slightly movable
• Diarthroses – freely movable
Fibrous Structural Joints
• The bones are jointed by fibrous tissues
• There is no joint cavity
• Most are immovable
• There are three
types – sutures,
syndesmoses,
and gomphoses
Fibrous Structural Joints: Sutures
• Occur between the bones of the skull
• Comprised of interlocking junctions completely filled with CT fibers
• Bind bones tightly together, but allow for growth during youth
• In middle age, skull bones fuse and are called synostoses
Fibrous Structural Joints: Syndesmoses
• Bones are connected by a fibrous tissue ligament
• Movement varies from immovable to slightly variable
• Examples include the connection between the tibia and fibula, and the radius and ulna
Fibrous Structural Joints: Gomphoses
• The peg-in-socket fibrous joint between a tooth and its alveolar socket
• The fibrous connection is the periodontal ligament
Cartilaginous Joints
• Articulating bones are united by cartilage
• Lack a joint cavity
• Two types – synchondroses and symphyses
Cartilaginous Joints: Synchondroses
• A bar or plate of hyaline cartilage unites the bones
• All synchondroses are synarthrotic
• Examples include:
• Epiphyseal plates of children
• Joint between the costal cartilage of the first rib and the sternum
Cartilaginous Joints: Symphyses
• Hyaline cartilage covers the articulating surface of the bone and is fused to an intervening pad of fibrocartilage
• Amphiarthrotic joints designed for strength and flexibility
• Examples include intervertebral joints and the p***c symphysis of the pelvis
Synovial Joints
• Those joints in which the articulating bones are separated by a fluid-containing joint cavity
• All are freely movable diarthroses
• Examples – all limb joints, and most joints of the body
Synovial Joints: General Structure
• Synovial joints all have the following:
• Articular cartilage
• Joint (synovial) cavity
• Articular capsule
• Synovial fluid
• Reinforcing ligaments
Synovial Joints: Friction-Reducing Structures
• Bursae – flattened, fibrous sacs lined with synovial membranes and containing synovial fluid
• Common where ligaments, muscles, skin, tendons, or bones rub together
• Tendon sheath – elongated bursa that wraps completely around a tendon
Synovial Joints: Stability
• Stability is determined by:
• Articular surfaces – shape determines what movements are possible
• Ligaments – unite bones and prevent excessive or undesirable motion
• Muscle tone is accomplished by:
• Muscle tendons across joints are the most important stabilizing factor
• Tendons are kept tight at all times by muscle tone
Synovial Joints: Movement
• Muscle attachment across a joint
• Origin – attachment to the immovable bone
• Insertion – attachment to the movable bone
• Described as movement along transverse, frontal, or sagittal planes
Synovial Joints: Range of Motion
• Nonaxial – slipping movements only
• Uniaxial – movement in one plane
• Biaxial – movement in two planes
• Multiaxial – movement in or around all three planes
Gliding Movements
• One flat bone surface glides or slips over another similar surface
• Examples – intercarpal and intertarsal joints, and between the flat articular processes of the vertebrae
Angular Movement
• Flexion
• Extension
• Dorsiflexion and plantar flexion of the foot
• Abduction
• Adduction
• Circumduction
Rotation
• The turning of a bone around its own long axis
• Examples:
• Between first two vertebrae
• Hip and shoulder joints
Special Movements
• Supination and pronation
• Inversion and eversion
• Protraction and retraction
• Elevation and depression
• Opposition
Types of Synovial Joints
• Plane joints
• Articular surfaces are essentially flat
• Allow only slipping or gliding movements
• Only examples of nonaxial joints
• Hinge joints
• Cylindrical projections of one bone fits into a trough-shaped surface on another
• Motion is along a single plane
• Uniaxial joints permit flexion and extension only
• Examples: elbow and interphalangeal joints
Pivot Joints
• Rounded end of one bone protrudes into a “sleeve,” or ring, composed of bone (and possibly ligaments) of another
• Only uniaxial movement allowed
• Examples: joint between the axis and the dens, and the proximal radioulnar joint
Condyloid, or Ellipsoidal, Joints
• Oval articular surface of one bone fits into a complementary depression in another
• Both articular surfaces are oval
• Biaxial joints permit all angular motions
• Examples: radiocarpal (wrist) joints, and metacarpophalangeal (knuckle) joints
Saddle Joints
• Similar to condyloid joints but with greater movement
• Each articular surface has both a concave and a convex surface
• Example: carpometacarpal joint of the thumb
Ball-and-Socket Joints
• A spherical or hemispherical head of one bone articulates with a cuplike socket of another
• Multiaxial joints permit the most freely moving synovial joints
• Examples: shoulder and hip joints
Synovial Joints: Shoulder (Glenohumeral)
• Ball-and-socket joint in which stability is sacrificed to obtain greater freedom of movement
• Head of humerus articulates with the glenoid fossa of the scapula
Synovial Joints: Shoulder Stability
• Weak stability is maintained by:
• Thin, loose joint capsule
• Four ligaments – coracohumeral, and three glenohumeral
• Tendon of the long head of biceps, which travels through the intertubercular groove and secures the humerus to the glenoid cavity
• Rotator cuff (four tendons) encircles the shoulder joint and blends with the articular capsule
Synovial Joints: Knee
• Largest and most complex joint of the body
• Allow flexion, extension, and some rotation
• Three joints in one surrounded by a single joint cavity
• Femoropatellar
• Lateral and medial tibiofemoral joints
Synovial Joints: Major Ligaments and Tendons – Anterior View
• Tendon of the quadriceps femoris muscle
• Lateral and medial patellar retinacula
• Fibular collateral ligament
• Tibial collateral ligament
• Patellar ligament
Synovial Joints: Knee –
Other Supporting Structures
• Anterior cruciate ligament
• Posterior cruciate ligament
• Medial meniscus (semilunar cartilage)
• Lateral meniscus
Synovial Joints: Knee – Posterior Superficial View
• Adductor magnus tendon
• Articular capsule
• Oblique popliteal ligament
• Arcuate popliteal ligament
• Semimembranosus tendon
Sprains
• The ligaments reinforcing a joint are stretched or torn
• Partially torn ligaments slowly repair themselves
• Completely torn ligaments require prompt surgical repair
Cartilage Injuries
• The snap and pop of overstressed cartilage
• Common aerobics injury
• Repaired with arthroscopic surgery
Dislocations
• Occur when bones are forced out of alignment
• Usually accompanied by sprains, inflammation, and joint immobilization
• Caused by serious falls and are common sports injuries
• Subluxation – partial dislocation of a joint
Inflammatory and Degenerative Conditions
• Bursitis
• An inflammation of a bursa, usually caused by a blow or friction
• Symptoms are pain and swelling
• Treated with anti-inflammatory drugs; excessive fluid may be aspirated
• Tendonitis
• Inflammation of tendon sheaths typically caused by overuse
• Symptoms and treatment are similar to bursitis
Arthritis
• More than 100 different types of inflammatory or degenerative diseases that damage the joints
• Most widespread crippling disease in the U.S.
• Symptoms – pain, stiffness, and swelling of a joint
• Acute forms are caused by bacteria and are treated with antibiotics
• Chronic forms include osteoarthritis, rheumatoid arthritis, and gouty arthritis
Osteoarthritis (OA)
• Most common chronic arthritis; often called “wear-and-tear” arthritis
• Affects women more than men
• 85% of all Americans develop OA
• More prevalent in the aged, and is probably related to the normal aging process
Osteoarthritis: Course
• OA reflects the years of abrasion and compression causing increased production of metalloproteinase enzymes that break down cartilage
• As one ages, cartilage is destroyed more quickly than it is replaced
• The exposed bone ends thicken, enlarge, form bone spurs, and restrict movement
• Joints most affected are the cervical and lumbar spine, fingers, knuckles, knees, and hips
Osteoarthritis: Treatments
• OA is slow and irreversible
• Treatments include:
• Mild pain relievers, along with moderate activity
• Magnetic therapy
• Glucosamine sulfate decreases pain and inflammation
• SAM-e (s-adenosylmethionine) builds up cartilage matrix and regenerates tissue
Rheumatoid Arthritis (RA)
• Chronic, inflammatory, autoimmune disease of unknown cause, with an insidious onset
• Usually arises between the ages of 40 to 50, but may occur at any age
• Signs and symptoms include joint tenderness, anemia, osteoporosis, muscle atrophy, and cardiovascular problems
• The course of RA is marked with exacerbations and remissions
Rheumatoid Arthritis: Course
• RA begins with synovitis of the affected joint
• Inflammatory blood cells migrate to the joint, causing swelling
• Inflamed synovial membrane thickens into a pannus
• Pannus erodes cartilage, scar tissue forms, articulating bone ends connect
• The end result, ankylosis, produces bent, deformed fingers
Rheumatoid Arthritis: Treatment
• Conservative therapy – aspirin, long-term use of antibiotics, and physical therapy
• Progressive treatment – anti-inflammatory drugs or immunosuppressants
• The drug Embrel, a biological response modifier, removes cells that promote inflammation
Gouty Arthritis
• Deposition of uric acid crystals in joints and soft tissues, followed by an inflammation response
• Typically, gouty arthritis affects the joint at the base of the great toe
• In untreated gouty arthritis, the bone ends fuse and immobilize the joint
• Treatment – colchicine, nonsteroidal anti-inflammatory drugs, and glucocorticoids
Developmental Aspects of Joints
• By embryonic week 8, synovial joints resemble adult joints
• Few problems occur until late middle age
• Advancing years take their toll on joints including:
• Ligaments and tendons shorten and weaken
• Intervertebral discs become more likely to herniate
• OA is inevitable, and all people of 70 have some degree of OA
• Prudent exercise (especially swimming) that coaxes joints through their full range of motion is key to postponing joint problems

Liver•      The largest gland in the body•      Superficially has four lobes – right, left, caudate, and quadrate•      ...
09/08/2019

Liver
• The largest gland in the body
• Superficially has four lobes – right, left, caudate, and quadrate
• The falciform ligament:
• Separates the right and left lobes anteriorly
• Suspends the liver from the diaphragm and anterior abdominal wall
• The ligamentum teres:
• Is a remnant of the fetal umbilical vein
• Runs along the free edge of the falciform ligament
Liver: Associated Structures
• The lesser omentum anchors the liver to the stomach
• The hepatic blood vessels enter the liver at the porta hepatis
• The gallbladder rests in a recess on the inferior surface of the right lobe
• Bile leaves the liver via
• Bile ducts which fuse into the common hepatic duct
• The common hepatic duct fuses with the cystic duct
• These two ducts form the bile duct
Microscopic Anatomy of the Liver
• Hexagonal-shaped liver lobules are the structural and functional units of the liver
• Composed of hepatocyte (liver cell) plates radiating outward from a central vein
• Portal triads are found at each of the six corners of each liver lobule
• Portal triads consist of a bile duct and
• Hepatic artery – supplies oxygen-rich blood to the liver
• Hepatic portal vein – carries venous blood with nutrients from digestive viscera
• Liver sinusoids – enlarged, leaky capillaries located between hepatic plates
• Kupffer cells – hepatic macrophages found in liver sinusoids
• Hepatocytes’ functions include:
• Production of bile
• Processing bloodborne nutrients
• Storage of fat-soluble vitamins
• Detoxification
• Secreted bile flows between hepatocytes toward the bile ducts in the portal triads
Homeostatic Imbalance
• Hepatitis – inflammation of the liver often due to viral infection
• Viruses causing hepatitis are catalogued has HVA through HVF
• HVA and HVE are transmitted enterically and cause self-limiting infections
• Hepatitis B is transmitted via blood transfusions, contaminated needles, and sexual contact, and increases the risk of liver cancer
• Hepatitis C produces chronic liver infection
• Nonviral hepatitis is caused by drug toxicity and wild mushroom poisoning
• Cirrhosis – diffuse and progressive chronic inflammation of the liver
• Typically results from chronic alcoholism or severe chronic hepatitis
• The liver becomes fatty and fibrous and its activity is depressed
• Scar tissue obstructs blood flow in the hepatic portal system causing portal hypertension
Composition of Bile
• A yellow-green, alkaline solution containing bile salts, bile pigments, cholesterol, neutral fats, phospholipids, and electrolytes
• Bile salts are cholesterol derivatives that:
• Emulsify fat
• Facilitate fat and cholesterol absorption
• Help solubilize cholesterol
• Enterohepatic circulation recycles bile salts
• The chief bile pigment is bilirubin, a waste product of heme
The Gallbladder
• Thin-walled, green muscular sac on the ventral surface of the liver
• Stores and concentrates bile by absorbing its water and ions
• Releases bile via the cystic duct which flows into the bile duct
Regulation of Bile Release
• Acidic, fatty chyme causes the duodenum to release:
• Cholecystokinin (CCK) and secretin into the bloodstream
• Bile salts and secretin transported in blood stimulate the liver to produce bile
• Vagal stimulation causes weak contractions of the gallbladder
• Cholecystokinin causes:
• The gallbladder to contract
• The hepatopancreatic sphincter to relax
• As a result, bile enters the duodenum
Homeostatic Imbalance
• Gallstones – crystallization of cholesterol which can obstruct the flow of bile
• Current treatments include: dissolving the crystals with drugs, pulverizing them with ultrasound, vaporizing them with lasers, and surgical removal of the gallbladder
• Obstructive jaundice – yellowish skin caused by bile pigments deposited in the skin
• Due to blocked bile ducts
Pancreas
• Location
• Lies deep to the greater curvature of the stomach
• The head is encircled by the duodenum and the tail abuts the spleen
• Exocrine function
• Secretes pancreatic juice which breaks down all categories of foodstuff
• Acini (clusters of secretory cells) contain zymogen granules with digestive enzymes
• The pancreas also has an endocrine function – release of insulin and glucagon
Composition and Function of Pancreatic Juice
• Water solution of enzymes and electrolytes (primarily HCO3)
• Neutralizes acid chyme
• Provides optimal environment for pancreatic enzymes
• Enzymes are released in inactive form and activated in the duodenum
• Examples include
• Trypsinogen is activated to trypsin
• Procarboxypeptidase is activated to carboxypeptidase
• Active enzymes secreted
• Amylase, lipases, and nucleases
• These enzymes require ions or bile for optimal activity
Regulation of Pancreatic Secretion
• Secretin and CCK are released when fatty or acidic chyme enters the duodenum
• CCK and secretin enter the bloodstream
• Upon reaching the pancreas:
• CCK induces the secretion of enzyme-rich pancreatic juice
• Secretin causes secretion of bicarbonate-rich pancreatic juice
• Vagal stimulation also causes release of pancreatic juice
Digestion in the Small Intestine
• As chyme enters the duodenum
• Carbohydrates and proteins are only partially digested
• No fat digestion has taken place
• Digestion continues in the small intestine
• Chyme is released slowly into the duodenum
• Because it is hypertonic and has low pH, mixing is required for proper digestion
• Required substances needed are supplied by the liver
• Virtually all nutrient absorption takes place in the small intestine
Motility of the Small Intestine
• The most common motion of the small intestine is segmentation
• It is initiated by intrinsic pacemaker cells (Cajal cells)
• Moves contents steadily toward the ileocecal valve
• After nutrients have been absorbed:
• Peristalsis begins with each wave starting distal to the previous
• Meal remnants, bacteria, mucosal cells, and debris are moved into the large intestine
Control of Motility
• Local enteric neurons of the GI tract coordinate intestinal motility
• Cholinergic neurons cause:
• Contraction and shortening of the circular muscle layer
• Shortening of longitudinal muscle
• Distension of the intestine
• Other impulses relax the circular muscle
• The gastroileal reflex and gastrin:
• Relax the ileocecal sphincter
• Allow chyme to pass into the large intestine
Large Intestine
• Has three unique features:
• Teniae coli – three bands of longitudinal smooth muscle in its muscularis
• Haustra – pocketlike sacs caused by the tone of the teniae coli
• Epiploic appendages – fat-filled pouches of visceral peritoneum
• Is subdivided into the cecum, appendix, colon, re**um, and a**l ca**l
• The saclike cecum:
• Lies below the ileocecal valve in the right iliac fossa
• Contains a wormlike vermiform appendix
Homeostatic Imbalance
• Appendicitis – inflammation of the appendix resulting from blockage that traps infectious bacteria in its lumen
• If the appendix ruptures, f***s containing bacteria spray over the abdominal contents causing peritonitis
• Treatment is surgical removal of the appendix
Colon
• Has distinct regions: ascending colon, hepatic flexure, transverse colon, splenic flexure, descending colon, and sigmoid colon
• The transverse and sigmoid portions are anchored via mesenteries called mesocolons
• The sigmoid colon joins the re**um
• The a**l ca**l, the last segment of the large intestine, opens to the exterior at the a**s
Valves and Sphincters of the Re**um and A**s
• Three valves of the re**um stop f***s from being passed with gas
• The a**s has two sphincters:
• Internal a**l sphincter composed of smooth muscle
• External a**l sphincter composed of skeletal muscle
• These sphincters are closed except during defecation
Large Intestine: Microscopic Anatomy
• Colon mucosa is simple columnar epithelium except in the a**l ca**l
• Has numerous deep crypts lined with goblet cells
• A**l ca**l mucosa is stratified squamous epithelium
• A**l sinuses exude mucus and compress f***s
• Superficial venous plexuses are associated with the a**l ca**l
• Inflammation of these veins results in itchy varicosities called hemorrhoids
Bacterial Flora
• The bacterial flora of the large intestine consist of:
• Bacteria surviving the small intestine that enter the cecum and
• Those entering via the a**s
• These bacteria:
• Colonize the colon
• Ferment indigestible carbohydrates
• Release irritating acids and gases (flatus)
• Synthesize B complex vitamins and vitamin K
Functions of the Large Intestine
• Other than digestion of enteric bacteria, no further digestion takes place
• Vitamins, water, and electrolytes are reclaimed
• Its major function is propulsion of f***l material toward the a**s
• Though essential for comfort, the colon is not essential for life
Motility of the Large Intestine
• Haustral contractions
• Slow segmenting movements that move the contents of the colon
• Haustra sequentially contract as they are stimulated by distension
• Presence of food in the stomach:
• Activates the gastrocolic reflex
• Initiates peristalsis that forces contents toward the re**um
Homeostatic Imbalance
• Diverticulosis – small herniation (diverticula) of the mucosa of the colon walls caused by lack of bulk in the colon
• Most common in the sigmoid colon in people over 70
• Diverticulitis – inflamed diverticula that can be life threatening if the diverticula rupture
Defecation
• Distension of re**al walls caused by f***s
• Stimulates contraction of the re**al walls
• Relaxes the internal a**l sphincter
• Voluntary signals stimulate relaxation of the external a**l sphincter and defecation occurs
Homeostatic Imbalance
• Diarrhea – watery stool resulting from any condition that rushes food residue through the large intestine too quickly
• This causes insufficient time for water absorption
• Prolonged diarrhea may result in dehydration and electrolyte imbalance
• Constipation – hard stool that is difficult to pass resulting from residues staying in the intestine too long
• May result from lack of fiber in the diet
Food Poisoning: Salmonella
• Salmonella is spread by:
• Contaminated eggs and egg products
• Infected food handlers with f***s-contaminated hands
• Salmonella can cause:
• Bacteremia 4 to 7 days after infection
• Endocarditis, thrombi, bone infections, arthritis, and meningitis
• Diagnosis is by positive stool samples
• Salmonellosis is treated symptomatically
Chemical Digestion: Carbohydrates
• Absorption: via cotransport with Na+, and facilitated diffusion
• Enter the capillary bed in the villi
• Transported to the liver via the hepatic portal vein
• Enzymes used: salivary amylase, pancreatic amylase, and brush border enzymes
Chemical Digestion: Proteins
• Absorption: similar to carbohydrates
• Enzymes used: pepsin in the stomach
• Enzymes acting in the small intestine
• Pancreatic enzymes – trypsin, chymotrypsin, and carboxypeptidase
• Brush border enzymes – aminopeptidases, carboxypeptidases, and dipeptidases
Chemical Digestion: Fats
• Absorption: Diffusion into intestinal cells where they
• Combine with proteins and extrude chylomicrons
• Enter lacteals and are transported to systemic circulation via lymph
• Glycerol and short chain fatty acids
• are absorbed into the capillary blood in villi
• transported via the hepatic portal vein
• Enzymes/chemicals used: bile salts and pancreatic lipase
Fatty Acid Absorption
• Fatty acids and monoglycerides enter intestinal cells via diffusion
• They are combined with proteins within the cells
• Resulting chylomicrons are extruded
• They enter lacteals and are transported to the circulation via lymph
Chemical Digestion: Nucleic Acids
• Absorption: active transport via membrane carriers
• Absorbed in villi and transported to liver via hepatic portal vein
• Enzymes used: pancreatic ribonucleases and deoxyribonuclease in the small intestines
Electrolyte Absorption
• Most ions are actively absorbed along the length of small intestine
• Na+ is coupled with absorption of glucose and amino acids
• Ionic iron is transported into mucosal cells where it binds to ferritin
• Anions passively follow the electrical potential established by Na+
• K+ diffuses across the intestinal mucosa in response to osmotic gradients
• Ca2+ absorption:
• Is related to blood levels of ionic calcium
• Is regulated by Vitamin D and parathyroid hormone (PTH)
Water Absorption
• 95% of water is absorbed in the small intestines by osmosis
• Water moves in both directions across intestinal mucosa
• Net osmosis occurs whenever a concentration gradient is established by active transport of solutes into the mucosal cells
• Water uptake is coupled with solute uptake, and as water moves into mucosal cells, substances follow along their concentration gradients
Malabsorption of Nutrients
• Results from anything that interferes with delivery of bile or pancreatic juice
• Factors that damage the intestinal mucosa (e.g., bacterial infection)
• Gluten enteropathy (adult celiac disease) – gluten damages the intestinal villi and reduces the length of microvilli
• Treated by eliminating gluten from the diet (all grains but rice and corn)
Embryonic Development of the Digestive System
• 3rd week – endoderm has folded and foregut and hindgut have formed
• The midgut is open and continuous with the yolk sac
• Mouth and a**l openings are nearly formed
• 8th week – accessory organs are budding from endoderm
Homeostatic Imbalance
• Cleft palate – palatine bones, palatine process of the maxillae (or both) fail to fuse
• Tracheoesophageal fistula – opening between the esophagus and trachea
• Cystic fibrosis – impairs pancreatic activity
Developmental Aspects
• During fetal life, nutrition is via the placenta, but the GI tract is stimulated toward maturity by amniotic fluid swallowed in utero
• At birth, feeding is an infant’s most important function and is enhanced by
• Rooting reflex (helps infant find the ni**le) and sucking reflex (aid in swallowing)
• Digestive system has few problems until the onset of old age
• During old age the GI tract activity declines, absorption is less efficient, and peristalsis is slowed
Cancer
• Stomach and colon cancers rarely have early signs or symptoms
• Metastasized colon cancers frequently cause secondary liver cancer
• Prevention is by regular dental and medical examinations
• Colon cancer is the 2nd largest cause of cancer deaths in males (lung cancer is 1st)
• Forms from benign mucosal tumors called polyps whose formation increases with age
• Regular colon examination should be done for all those over 50

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